Posted on April 18th, 2025

In the world of non-surgical aesthetics, two treatments consistently steal the spotlight for their ability to restore youthfulness and revitalise tired skin: Profhilo and dermal fillers. Both offer incredible skin-rejuvenating benefits, yet they work in entirely different ways. At Macs of London Medical Aesthetics & Wellness Clinic, we’re often asked: "Which one is right for me?" and today, we're here to guide you through that answer. Whether you’re looking to address sagging skin, dullness, fine lines, or volume loss, understanding the difference between Profhilo and fillers is key to choosing the treatment that suits your skin goals, lifestyle, and desired results.

What Is Profhilo?

Profhilo is an award-winning, bio-remodelling injectable treatment that contains one of the highest concentrations of pure hyaluronic acid on the market. Unlike dermal fillers, which are designed to add volume or structure to specific areas, Profhilo spreads beneath the skin to deeply hydrate and stimulate collagen and elastin production.

The result? A natural, radiant glow, improved skin texture, increased firmness, and enhanced elasticity — all without altering your facial features.

How it works

Profhilo is injected into five strategic points on each side of the face using the Bio Aesthetic Points (BAP) technique. It disperses smoothly under the skin and integrates with your tissue, providing a subtle but powerful lift.

Best For

- Dull, crepey, or dehydrated skin

- Fine lines and early signs of ageing

- Overall skin quality improvement

- Those seeking natural-looking, subtle rejuvenation

• Treatment areas: Face, neck, décolletage, hands, arms, and even knees.
• Sessions required: Typically two sessions, four weeks apart.
• Results last: Around six months, depending on lifestyle and skin condition.

What Are Dermal Fillers?

Dermal fillers are gel-like substances (often made from hyaluronic acid as well) that are injected beneath the skin to restore lost volume, contour facial features, and smooth deeper lines or wrinkles. Fillers are more structural in nature, making them ideal for lifting, plumping, and reshaping specific facial areas.

How They Works

Dermal fillers are injected directly into targeted areas to sculpt, enhance, or replace volume that diminishes with age.

Best For

- Restoring lost volume in cheeks or temples

- Enhancing lips or jawline

- Smoothing deep lines (e.g. nasolabial folds, marionette lines)

- Non-surgical rhinoplasty

• Treatment areas: Cheeks, lips, jawline, chin, temples, nose, tear troughs, hands.
• Sessions required: Often one session, with top-ups as needed.
• Results last: 6 to 18 months, depending on the type of filler used and the area treated.

Key Differences: Profhilo vs Dermal Fillers

Primary Purpose

• Profhilo: Hydration and collagen stimulation

• Dermal Fillers: Volume restoration and contouring

Consistency

• Profhilo: Thin, honey-like texture

• Dermal Fillers: Thicker gel consistency

Placement

• Profhilo: Broad, under-the-skin distribution

• Dermal Fillers: Precisely targeted to specific facial areas

Results

• Profhilo: Firmer, radiant, naturally glowing skin

• Dermal Fillers: Sculpted features with added volume and lift

Downtime

• Profhilo: Minimal downtime

• Dermal Fillers: Minimal to moderate, depending on the area treated

Natural Look

• Profhilo: Ultra-natural, subtle refresh

• Dermal Fillers: Can range from natural to more defined, based on desired outcome

Which One Is Right for You?

It all depends on your goals. At Macs of London, we take a personalised approach to aesthetics — there’s no one-size-fits-all. Here’s a quick guide to help you decide:

Choose Profhilo If:

- Your skin feels dry, dull, or tired-looking

- You’re experiencing mild skin laxity or early ageing signs

- You want to boost hydration and glow without changing your facial structure

- You prefer a subtle, natural refresh

Choose Dermal Fillers If:

- You’ve lost volume in specific areas (cheeks, under-eyes, lips)

- You want to define or contour your features

- You’re looking to smooth deeper lines or enhance facial symmetry

- You’re open to more sculpted, noticeable changes

Can You Combine Profhilo and Fillers?

Absolutely — in fact, it’s often the gold standard. Profhilo and dermal fillers complement each other beautifully when used strategically. 

For example:

- Profhilo boosts skin quality, hydration, and firmness

- Fillers then enhance specific features (like the cheeks or jawline) for a complete, harmonious result

We call this approach “skin from within meets structure enhancement.” When expertly performed, the result is a naturally refreshed, balanced, and youthful appearance.

Your Experience at Macsoflondon

From the moment you walk into our clinic at Piano House in Brixton, you're welcomed into a space where your comfort and care are our priority. Our expert medical practitioners specialise in natural-looking, subtle enhancements — prioritising safety, expertise, and bespoke treatment planning.

Each consultation is personalised. We take time to understand your goals, lifestyle, and skin health before recommending a tailored approach — whether that’s Profhilo, fillers, or a combination of both.

Frequently Asked Questions

• Is there any downtime with Profhilo or fillers?

Most clients experience minimal downtime. You may notice slight redness or small bumps (especially with Profhilo), which typically resolve within 24–48 hours.

• Do the injections hurt?

Both treatments use ultra-fine needles and are relatively comfortable. Numbing cream is available for added comfort during filler procedures.

• When will I see results?

- Profhilo: Full results develop gradually after the second session — usually by week 6–8.

- Fillers: Results are visible immediately, with final settling in 1–2 weeks.

• Are the results permanent?

No — both treatments are temporary, non-surgical solutions designed to enhance natural beauty. Maintenance is recommended every 6–12 months depending on your treatment plan.

Ready to Discover What’s Right for You?

At Macsoflondon, we’re here to help you look and feel your best — naturally. Whether you’re curious about Profhilo, dermal fillers, or a combination of both, our expert team is ready to guide you.

✨ Book your personalised consultation today and start your journey towards radiant, confident skin.

👉 Book Now 

Macsoflondon Medical Aesthetics & Wellness Clinic Piano House, Brixton  

London’s trusted destination for advanced non-surgical aesthetics and wellness.