In the ever-evolving world of aesthetic medicine, a new era of skin rejuvenation has arrived—one that doesn’t focus on adding volume or masking imperfections, but on awakening the skin’s innate ability to repair, regenerate, and renew. At the forefront of this movement are Polynucleotides, the latest breakthrough in regenerative injectables.

While many injectable treatments focus on enhancing volume or surface-level hydration, Polynucleotides work at a much deeper level—stimulating true tissue repair and skin regeneration at the cellular level. For those seeking a more natural, subtle, and biologically intelligent approach to skin revitalisation, Polynucleotides represent a new gold standard.

What Are Polynucleotides?

Polynucleotides are fragments of DNA extracted from natural sources—typically purified salmon DNA—that have remarkable biological properties when introduced into the skin. These naturally occurring molecules act as biostimulators, encouraging the skin to regenerate from within by boosting fibroblast activity, supporting collagen and elastin production, and improving tissue oxygenation.

Polynucleotides work by creating an ideal environment for cell proliferation and repair. Unlike dermal fillers that add volume or structure, these injectables provide the biological tools your skin needs to rebuild itself, improving tone, elasticity, hydration, and overall texture.

• llagen and elastin production
• Promoting deep hydration through improved extracellular matrix support
• Reducing oxidative stress, thanks to their anti-inflammatory properties

The result is healthier, stronger, and visibly smoother skin over time—without adding bulk or risking unnatural contours.

What Makes Polynucleotides Different?

The beauty of Polynucleotides lies in their regenerative intelligence. Rather than adding volume (as with dermal fillers) or simply hydrating (as with traditional skin boosters), Polynucleotides initiate true skin healing. They are particularly ideal for clients looking to treat:

• Under-eye hollows, crepey skin or dark circles
• Fine lines and early skin laxity
• Acne scarring or post-inflammatory pigmentation
• Overall dullness or skin fatigue
• Thinning skin due to age, lifestyle or stress

They’re safe for all skin types and tones, and are often recommended for clients seeking natural-looking results without the use of volume-enhancing agents.

Who Is It Best For?

Polynucleotides are suitable for a wide range of clients—from those in their late 20s beginning to notice changes in skin quality, to more mature clients looking to restore firmness, brightness, and clarity.

They are especially popular among clients who:

• Prefer subtle, non-obvious rejuvenation
• Want to improve skin quality without traditional fillers
• Are concerned with fragile or hard-to-treat areas like the under-eyes or neck
• Seek long-term improvement, not just short-term enhancement

Treatments are comfortable, minimally invasive, and offer minimal downtime, making them ideal for busy professionals or those seeking refined results without disruption to their daily routine.

What to Expect from Treatment

At Macs of London, we deliver Polynucleotide treatments with the highest level of precision and care. After a full consultation, a series of tiny injections are delivered just beneath the surface of the skin. Most clients require a course of 2–3 sessions, spaced a few weeks apart, followed by occasional maintenance.

Clients often report an improvement in texture, tone, and glow within 2–3 weeks, with cumulative results continuing to build in the months that follow.

Post-treatment, you may experience slight redness or swelling, which typically resolves within 24–48 hours. There’s no need for extended downtime.